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Lecture
Protein Circuit Design: Signal Transmission and Dynamic Control
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Protein Structure: General Principles
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Covers the principles and challenges of computational protein design in bioengineering.
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Explores NMR spectroscopy for protein structure determination and introduces Cryo-EM as a complementary technique with recent advancements.
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Covers protein design fundamentals, including secondary structures, amino acid propensity, loops, and computational methods.
Proteins and Allostery
Explores proteins' structure, function, cooperativity, and allostery, including action at a distance and protein evolution.
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Explores proteomics for post-translational modifications and protein interactions.
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Explores protein composition, peptide bonds, structures, folding, and stability.
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Covers the mechanisms of protein degradation, including the roles of the proteasome and autophagy in regulating protein function.
Protein Design: Structure and Function
Explores protein design challenges, validation through crystallography, evolution of design techniques, and the difference between genetic and protein circuits.
Protein Co-evolution Analysis
Delves into protein co-evolution analysis, covering discoveries, residue contacts, and direct coupling analysis.