Lecture
This lecture explores the different modes of action of drugs, focusing on enzyme inhibition, reversible and irreversible binding, and covalent drugs. It covers topics such as transition-state analogs, drug activity evaluation, and examples of covalent drugs. The instructor discusses experimental methods to evaluate drug reversibility and the impact of slow on/off inhibitors. Additionally, the lecture delves into the concept of irreversible inactivation and the efficacy of reversible and irreversible inhibitors. Various examples of covalent drugs throughout history are presented, highlighting their mechanisms and significance in medicine.