Kinase Inhibitors: Types and Mechanisms

This lecture covers the classification and mechanisms of kinase inhibitors, focusing on their role in cancer treatment. It discusses the different types of kinase inhibitors based on their interaction sites and the significance of aspartate residues in ATP-binding sites. The lecture also delves into enzyme inhibition methods, including reversible and irreversible inhibition, with a particular emphasis on transition state analog drugs. Furthermore, it explores the concept of transition state inhibitors and their unique structural features. The session concludes with a detailed analysis of covalent drugs, highlighting their increasing importance in pharmaceutical research.