Arterial Stenoses: Physiology and Clinical Significance

This lecture covers the pathophysiology of arterial stenoses, focusing on atherosclerosis development, coronary remodeling, pressure-flow relations, and the physiological and clinical significance of stenosis. It explains the progression of stenosis, the role of inflammation in plaque rupture, and the distinction between stable and unstable plaques. The instructor also discusses percutaneous coronary intervention, coronary flow reserve, fractional flow reserve, and coronary pressure measurements. The lecture concludes with a detailed explanation of the FFR method for coronary pressure measurements. Overall, it provides a comprehensive overview of arterial stenoses and their implications in cardiovascular health.