This lecture focuses on the advancements in translational neuroengineering, particularly in the development of bionic artificial limbs. It begins with a summary of previous discussions on restoring a natural bi-directional link between artificial limbs and the nervous system. The instructor explains key concepts such as under-actuation and non-backdrivability in prosthetic design, emphasizing their importance for functionality. The lecture then delves into the various interfaces used in neuroengineering, highlighting the balance between selectivity and invasiveness. The discussion includes targeted muscle reinnervation, which involves rerouting nerves to enhance control over prosthetic devices. The instructor also covers sensory feedback mechanisms, demonstrating how real-time feedback can improve user experience and acceptance of prosthetics. The lecture concludes with insights into biomimetic encoding strategies, exploring how different stimulation methods can enhance the naturalness of sensations experienced by users. Overall, the lecture provides a comprehensive overview of the challenges and innovations in the field of neuroprosthetics, aiming to improve the quality of life for individuals with limb loss.