This lecture covers the orientation dependence of fatigue, anisotropy in Titanium alloys, and the Larson-Miller concept for creep. It discusses improving fatigue endurance with shot peening, anisotropy in a-Ti and a+ß alloys, creep-resistant titanium alloys, and the Larson-Miller parameter for creep resistance. The presentation also highlights the use of Titanium alloys for their superior corrosion resistance, specific strength, and excellent fatigue strength.