Design of Immunogenic Vaccines

This lecture covers the design of immunogenic vaccines, focusing on boosting the immune response through synthetic biology, nano-engineering, and local delivery. It discusses the impact, history, and concepts of vaccines, including those against COVID-19. The lecture also explores successful and licensed vaccine classes, challenges in vaccine development for diseases like HIV and malaria, and the history of immunotherapy. It delves into the use of adjuvants in modern vaccines, the importance of antigens in T-cell response, and the feasibility and safety of neoantigen cancer vaccines. The presentation concludes with strategies to recruit dendritic cells to vaccine-loaded biomaterials and improve vaccine delivery across skin barriers.