Programmed Cell Death: Mechanisms and Implications

This lecture covers the discovery and major types of programmed cell death, focusing on apoptosis and autophagy. It explains the characteristics of apoptotic cells, illustrated with examples. The instructor discusses the lineage analysis in C. elegans and the discovery of apoptosis in this model organism. The lecture also delves into the intrinsic and extrinsic pathways of cell death, instances of apoptosis in vertebrates, and the role of autophagic cell death. Furthermore, it explores the necessity and sufficiency of apoptosis in processes like basal head regeneration in Hydra and salamander limb regeneration. The session concludes with insights into liver regeneration mechanisms and the key points of the discussed topics.