Apoptosis: Regulation and Signaling

This lecture covers the distinctive features of apoptosis, the role of caspases, the intrinsic and extrinsic pathways, and the detection methods of apoptosis. It also discusses the impact of apoptosis on tumor volume, the role of Bcl-2 family proteins, and the survival signaling pathways of Akt and mTOR. Furthermore, it explores the dual role of autophagy in cancer, the formation of autophagosomes, and the outcomes of autophagy induction. Key concepts include the regulation of apoptosis by various factors and the challenges faced in targeting mTOR for cancer therapy.