This lecture covers the process of testing a synapse model in a neuron using NEURON software. Starting with creating a single compartment soma neuron to host the synapse, the instructor guides through configuring the passive biophysics, creating the synapse, defining the stimulus, and setting up a recorder for synaptic conductance, current, soma voltage, and time intervals. The lecture also delves into the dual exponential model for the conductance time course, validating the trajectory for the NMDA receptor, and configuring the synapse to realistic biological ranges for AMPA and NMDA conductances. The session concludes with plotting the conductance trajectories and validating the model against a closed form solution.