Catalytic Radical Processes: Asymmetric Synthesis of Cyclobutanones

This lecture discusses a novel catalytic radical process involving 1,4-hydrogen atom abstraction for the asymmetric construction of cyclobutanones. The instructor presents the motivation behind the research, highlighting the importance of four-membered rings in natural products and pharmaceuticals. The lecture details the catalytic cycle, emphasizing the role of cobalt metalloradicals and the computational methods used to confirm the reaction mechanisms. The instructor explains the experimental methods employed to detect radical intermediates, confirming the presence of these intermediates through high-resolution mass spectrometry and electron paramagnetic resonance spectroscopy. The discussion includes the scope of the reaction, diastereoselectivity, and the development of catalysts that achieve high enantioselectivity. The practical applications of the synthesized compounds in organic synthesis are also covered, showcasing their potential in creating complex chiral molecules. The lecture concludes with a critical analysis of the process's novelty, practicability, and sustainability, addressing both the strengths and limitations of the catalytic system.