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This lecture covers the fundamental aspects of ion channels, including their structure, function, and classification. It explores the importance of ion channels in brain function, the mechanisms by which they allow ions to pass through membranes, and the various types of ion channels known in mammals. The lecture also delves into the role of ion channels in single-cell membrane potential, membrane permeability, and the biophysical models used to study ionic currents. Additionally, it discusses the significance of ion channels in various diseases, the methods used to study and model ion channels, and the future directions of ion channel research.