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This lecture discusses the synthesis of ATP in anaerobic cells, focusing on the endergonic reaction and its coupling with an exergonic reaction to degrade glucose into lactic acid. The instructor explains the balance equations for the reactions, the calculation of free energy changes, and the determination of reaction spontaneity. The lecture also covers the use of enthalpies and free energies to calculate reaction values, as well as the percentage of free energy used in ATP synthesis from glucose degradation. The comparison of energy efficiency in biological standard conditions versus actual cell conditions is explored, highlighting the higher efficiency in cellular energy production.