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This lecture explores the potential of two-dimensional materials (2DMs) for electronic applications, addressing issues and providing engineering perspectives. Topics include the history of 2DMs, graphene properties, and the challenges faced by the technology. The lecture also covers the motivations for using 2DMs, such as their high performance and flexibility, and their role in enabling wearable electronics and IoT devices. The instructor presents recent research results and discusses the future of electronic applications enabled by 2DMs.