Proteostasis Regulation: Chaperone Interactions and Post-Translational Modifications

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Hsp70 Chaperone Binding: Substrate Selectivity and Function

Explores the selective promiscuity in binding of the E. coli Hsp70 chaperone to unfolded or misfolded protein substrates, examining its implications in protein folding mechanisms.

Single Molecule Studies: Hsp90 Chaperone

Explores single-molecule studies of the Hsp90 chaperone and protein function using optical tweezers.

Proteins: Central Dogma and Translation

Explains protein synthesis, translation, and the central dogma of molecular biology.

Protein Folding: Non-equilibrium Dynamics

Explores protein folding dynamics, focusing on chaperone-assisted non-equilibrium stabilization and its implications for biophysics and evolution.

BiP-mediated ER quality control: assists and hurdles

Delves into BiP-mediated ER quality control, addressing protein folding, degradation, and unique challenges in B cell development.

Computational Protein Design

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Chaperone-Mediated Disaggregation: Amyloid Fibrils and Hsp70

Explores chaperone-mediated disaggregation of amyloid fibrils by Hsp70 in neurodegenerative diseases.

Protein self-assembly and phase transitions

Delves into protein self-assembly, phase transitions, and aggregation mechanisms in diseases like Alzheimer's.