Computational Protein Design

This lecture series on Synthetic Biology covers the journey from molecules to circuit to cell engineering, focusing on nucleic acid engineering, protein design, gene circuits, metabolic pathway engineering, protein circuits, and cell engineering. The instructor discusses the challenges in protein structure prediction and design, applications of computational protein design, and the importance of protein design in bioengineering and synthetic biology. The lecture also delves into the process of designing proteins, both experimentally and computationally, highlighting the significance of protein structures in determining protein function. Various topics such as the energy function for scoring the Global Minimum Energy Conformation (GMEC), atomic interactions in proteins, and the sampling methods for protein conformation exploration are explored.