Lecture

Protein Design: Dynamic Allosteric Pathways

Description

This lecture covers the computational modeling and design of dynamic allosteric pathways in proteins, focusing on the reprogramming of membrane receptor signaling and the repurposing of dopamine D2 receptors into serotonin biosensors. It discusses the structural diversity of D2 receptor agonists, the encoding of switching properties, and the development of GPCR biosensors with high sensitivity and selectivity.

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Official source

https://mediaspace.epfl.ch/media/0_gcvlflc3

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