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This lecture covers the biomechanical considerations and clinical treatments related to knee implants. It discusses lower limb alignment, tibial osteotomy, unicompartmental knee arthroplasty, and total knee arthroplasty. The instructor explains the importance of correcting misalignment through osteotomy, evaluating mechanical effects, and testing different scaffold shapes. The lecture also delves into the development process of new knee implants, including market analysis, biomechanical analysis, and in vitro testing. Furthermore, it explores the challenges of knee implant revisions, wear particle quantification, and in vitro testing on knee simulators.