This lecture covers the development of a patient-specific numerical musculoskeletal knee model focusing on patellar resurfacing in total knee arthroplasty. It discusses the clinical problem, model objectives, knee and patellar models, validation, and material properties identification. The instructor presents the application of the model to evaluate patellar strain, the influence of patellar cut on mechanics, and the correlation between strain and patient parameters. Results include kinematics, forces, strain distribution, and correlations with bone mineral density and body mass index. The lecture concludes with the potential of the model as a surgery planning tool and outlines future clinical applications.