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This lecture discusses the energy-efficiency in datacenters, focusing on the challenges and solutions to reduce power consumption and heat generation. It covers topics such as the advantages of 3D vs. 2D Multi-Processor System-on-Chip (MPSoCs), run-time heat spreading, liquid cooling technologies, and predictive energy management. The presentation also delves into the design of 3D MPSoCs with advanced cooling, thermal modeling, and active cooling management strategies. Various experiments and comparisons are presented to showcase the effectiveness of different thermal management approaches in achieving energy efficiency and reducing hotspots.