Crystallization in COBRs

This lecture covers the enhancement of crystallization processes using Continuous Oscillatory Baffled Reactors (COBRs) in the context of Process Intensification and Green Chemistry. It discusses the advantages and disadvantages of COBRs, methods of generating supersaturation, nucleation mechanisms, growth kinetics, and the comparison between batch and continuous crystallizers. The lecture also explores the benefits of seeded cooling crystallization in COBRs and provides a real-world example of API isolation and purification by crystallization at AstraZeneca. Furthermore, it delves into the consequences of running processes in batch reactors, the limits of batch reactor process optimization, and the potential advantages of continuous reactors in terms of safety, productivity, and quality.