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This lecture explores the dynamics of active matter in biological systems, focusing on cell motility, polarity, and signaling pathways. It covers topics such as the impact of chirality disorder, topological defects, and the role of cell-cell interactions in tissue morphogenesis. The presentation delves into models like the Vicsek model and the phase field model, discussing how they capture the behavior of active materials. The instructor discusses the interplay between cell mechanics, polarity, and signaling in shaping spatial patterns of signaling proteins. The lecture concludes with insights into the implications of cell motility and polarity on tissue development and the formation of complex biological structures.