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This lecture delves into the structure of SARS-CoV-2, exploring key proteins and their functions in viral replication. It discusses potential antiviral strategies, such as main protease inhibitors and virucidal materials, highlighting their efficacy in inhibiting viral attachment and replication. The presentation covers in vitro and ex vivo studies, showcasing the effectiveness of various compounds in combating viral infections. Insights from cryo-TEM studies and in vivo experiments provide a comprehensive understanding of the mechanisms behind antiviral activity. The lecture also touches upon the classification of viruses based on attachment ligands and the importance of cyclodextrins in antiviral therapy.