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This lecture covers the histological structure of the spleen, focusing on the capsule, white pulp, red pulp, trabeculae, and circulation within the organ. It explains the differences in smooth muscle content between human and mammalian spleens, the components of white pulp, and the circulation pathways involving central and trabecular arteries. Practical implications of splenic dysfunction, such as increased risk of sepsis and thromboembolic complications, are also discussed, along with recommendations for patient education and prophylactic vaccinations.