Non Viral Vectors

This lecture discusses the advancements in non-viral vectors for delivering nucleic acids, such as physical methods like direct injection or enhancing membrane passage with electric or physical shocks. These methods offer precise delivery control and high loading capacity, with reduced immunogenicity compared to viral vectors. However, they suffer from low transfection efficiency and short-term expression, making them less suitable for long-term gene therapy, especially in slowly progressing neurological diseases.