Decoding Mechanisms of Alzheimer's Disease Risk

This lecture by Priyanka Narayan, a Stadtman Investigator at the National Institutes of Health, delves into the mechanisms behind the risk of Alzheimer's disease. With over 30 million individuals worldwide affected by Alzheimer's, the lecture explores genetic risk factors, such as APOE4, and their impact on lipid metabolism. Through studies on isogenic iPSC-derived cell types and yeast models, the lecture uncovers how APOE4 sensitizes cells and disrupts pathways, leading to cellular vulnerability. The research aims to identify pathway disruptions and potential therapeutic strategies to combat Alzheimer's disease.