Protein Lipidation: Membrane Organization

This lecture covers the covalent modification of proteins with lipids, focusing on the localisation of proteins within membranes, lipidation processes such as GPI anchors, prenylation, myristoylation, and palmitoylation, and the modulation of signalling pathways. It discusses the major classes of membrane lipids, lipid asymmetry in eukaryotic membranes, and the impact of lipid modifications on protein localisation and function. The lecture also explores the dynamic nature of lipid modifications, the role of lipid probes in identifying lipidated proteins, and the significance of protein lipidation in cellular processes. Various examples of lipidated proteins and their roles in membrane organisation and signalling are presented.