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This lecture discusses the structure of the plasma membrane, focusing on the selective permeability and the presence of cholesterol. It also covers the composition of fatty acids in E. coli cells at different temperatures and the role of proteins in the membrane. The lecture explains the structure of proteins, the primary, secondary, tertiary, and quaternary structures, and the folding process of a polypeptide chain. It also introduces the different types of amino acids and their properties, as well as the formation of peptide bonds. The importance of correctly folded proteins for biological activity is highlighted, along with the secondary structures like alpha helix and beta sheet.