This lecture covers the concepts of chemical thermodynamics, focusing on entropy, enthalpy, and Gibbs energy. It explains the molecular interpretation of these functions, their state variables nature, and their role in chemical reactions. The lecture also delves into the concept of enthalpy, the relationship between heat and work, and the spontaneity of reactions based on Gibbs energy. Furthermore, it discusses the entropy of isolated systems, the variation of entropy during chemical reactions, and the equilibrium constant. The presentation concludes with a detailed explanation of chemical equilibrium, the activity of chemical species, and the equilibrium constant's definition.