Lecture
This lecture delves into the Warburg Effect, a phenomenon where cancer cells exhibit altered glucose metabolism. It covers the historical background, computational studies, model construction, and analysis of kinetic models describing the Warburg Effect in breast cancer cells. The lecture explores the optimization of kinetic models, sampling parameters, metabolic pathways, and the estimation of maximum activity to achieve target flux. It also discusses the selection of physiologically relevant parameter sets, metabolic responses to perturbations, and the application of Metabolic Control Analysis to investigate lactate production in cancer cells.