This lecture covers the pharmacology of pain, focusing on the four steps in pain sensation: transduction, conduction, transmission/modulation, and perception. It discusses nociceptive pain, sensitizing agents, central and peripheral sensitization, opioid receptor agonists, NSAIDs, and the mechanism of action of various drugs. The presentation also delves into the effects of NSAIDs, opioids, and other related drugs, as well as the treatment of neuropathic pain and migraine therapy.