Personalized Health through the Eyes of a Fly

This lecture explores the use of fruit flies as avatars for personalized health, focusing on a case study of a patient with treatment-resistant colorectal cancer. It delves into the development of a personalized therapy using genomic analysis and robotics-based screening, leading to a significant treatment response. The lecture also covers the genetic variation in gut immunocompetence, the impact of mitochondrial genomic variation on health, and the influence of the gut microbiota on infection resistance. Additionally, it discusses the genetic determinants of circadian rhythms and the role of Drosophila in driving personalized health through genetic tools and functional screens.