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This lecture covers the basic concepts of classical and statistical thermodynamics, focusing on the first principle and enthalpy. It explains the molecular interpretation of thermodynamic functions, the state functions, and the variation of internal energy. The lecture also delves into the first law of thermodynamics, heat exchange, and work done by the system. Furthermore, it discusses the measurement of heat in different reactions, enthalpy change at constant pressure, and the distinction between endothermic and exothermic processes. The importance of enthalpy in chemical reactions, the Hess law, and binding enthalpies are also explored.