Stereoselective Synthesis: Wittig and Julia Reactions

This lecture covers the stereoselective synthesis of organic compounds through the Wittig and Julia reactions, focusing on the use of phosphorus ylides and sulfones. It explains the mechanisms, variations, and applications of these reactions, including hydroboration and reduction of alkenes. The lecture also discusses the Julia-Kocienski reaction, highlighting the importance of strong non-nucleophilic bases and solvation of metal cations in achieving stereoselectivity. Additionally, it explores the reduction of alkenes and the oxidation of alkenes, emphasizing the reactivity and regioselectivity of different carbocations. The use of borane and its derivatives as reagents for stereoselective reduction is also addressed.