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This lecture covers the composition and structure of DNA and RNA, including the components of DNA such as nucleotides and the sugar-phosphate backbone. It explores the bases, nucleosides, and nucleotides, as well as the X-ray structure of DNA. The discovery of DNA, the connectivity of DNA, and the DNA structure by James Watson and Francis Crick are discussed. The lecture also delves into DNA replication, the semi-conservative replication model, and the replication process in cells. Additionally, it explains the genetic code, the differences between DNA and RNA, and the role of RNA in protein synthesis.