Lymphocytic B and T Cell Receptors

This lecture covers the generation of B and T cell repertoires, focusing on the B and T lymphocytic receptors. The B cell receptor (BCR) is a membrane-bound immunoglobulin responsible for antigen binding and B cell activation. The BCR interacts with a co-receptor called CD79, containing ITAM motifs for signaling. The T cell receptor (TCR) is composed of alpha and beta chains connected by a disulfide bridge, recognizing antigens presented by Mhc molecules. The TCR also interacts with a co-receptor, CD3, essential for T cell activation. Other lymphoid cells expressing antigen receptors, such as gamma delta T cells and NKT cells, are briefly mentioned. A comparison between BCR and TCR highlights their structural differences and antigen recognition specificities.