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This lecture on photomedicine covers the history of the field, starting from the first studies in the early 90s to the first approval in 1999. It delves into the anatomy of the human eye, the aging process of the macula, and the formation of disciform scars. The lecture also explains the mechanism of action of Verteporfin-based photodynamic therapy (PDT) and its application in treating age-related macular degeneration. Various aspects of PDT with Visudyne®, including treatment procedures and effects, are discussed. The lecture concludes with a detailed explanation of the photometry and radiometry concepts related to light-tissue interactions.