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Explores enzyme activity modulation and small-molecule drug mechanisms, focusing on reversible and irreversible inhibition, progress curves, and covalent bond formation.
Covers enzyme inhibition mechanisms, drug modes of action, targeted protein degradation using PROTACs, and the bump-hole method for protein-ligand engineering.
Explores kinase inhibitors, enzyme inhibition methods, transition state analog drugs, and the significance of covalent drugs in pharmaceutical research.
Explores Chemical Biology's interdisciplinary nature, enzyme inhibition, genetic methods, and metabolic regulation, highlighting its real-world relevance through recent Nobel Prize contributions.
