Organoids: Model Systems in Tissue Engineering

This lecture explores the development and applications of organoids, miniature in vitro constructs mimicking in vivo tissues. It covers the historical path to organoid creation, cell/tissue culture approaches, stem cell-based morphogenesis, and the main features of organoids. The lecture delves into the derivation of organoids, the physical features of the culture environment, and the system-autonomous and exogenous signals involved. It also discusses models of organogenesis, early development, homeostasis, regeneration, disease modeling, drug discovery, and personalized medicine using organoids. The lecture highlights the potential of organoids in disease modeling, drug screening, and regenerative medicine, showcasing their role in understanding genetic diseases, host-pathogen interactions, and cancer modeling.