Molecular machines involved in mycobacterial protein quality control pathways

Description

This lecture by Eilika Weber-Ban from ETH Zürich explores the molecular machines involved in mycobacterial protein quality control pathways, focusing on the degradation pathways in protein homeostasis, the compartmentalizing proteases in Mycobacterium tuberculosis, and the pupylation-dependent proteasomal degradation pathway. The lecture delves into the recognition of Clp substrate classes, the asymmetric nature of Mycobacterial ClpP, and the role of Pup as a recruitment tag and threading initiator. It also discusses the importance of Mpa-proteasome complex in substrate selection, the depupylation rates of different substrates, and the mechanism and evolutionary origin of pupylation enzymes.

Official source

https://mediaspace.epfl.ch/media/0_ow78go48

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Molecular machine

Molecular machines are a class of molecules typically described as an assembly of a discrete number of molecular components intended to produce mechanical movements in response to specific stimuli, mimicking macromolecular devices such as switches and motors. Naturally occurring or biological molecular machines are responsible for vital living processes such as DNA replication and ATP synthesis. Kinesins and ribosomes are examples of molecular machines, and they often take the form of multi-protein complexes.

Molecular motor

Molecular motors are natural (biological) or artificial molecular machines that are the essential agents of movement in living organisms. In general terms, a motor is a device that consumes energy in one form and converts it into motion or mechanical work; for example, many protein-based molecular motors harness the chemical free energy released by the hydrolysis of ATP in order to perform mechanical work. In terms of energetic efficiency, this type of motor can be superior to currently available man-made motors.

Molecular assembler

A molecular assembler, as defined by K. Eric Drexler, is a "proposed device able to guide chemical reactions by positioning reactive molecules with atomic precision". A molecular assembler is a kind of molecular machine. Some biological molecules such as ribosomes fit this definition. This is because they receive instructions from messenger RNA and then assemble specific sequences of amino acids to construct protein molecules. However, the term "molecular assembler" usually refers to theoretical human-made devices.

Synthetic molecular motor

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Molecular propeller

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