Drug Delivery and Targeting

This lecture delves into biomaterials for drug delivery, covering naturally derived and manmade biomaterials, polymers, nanoparticles, surfaces, materials for cell adhesion, immune engineering, and tissue engineering. It explains the importance of targeting in drug delivery, the challenges faced, and strategies to improve nanoparticle therapeutics through specific and selective targeting. The lecture also discusses passive vs active targeting, the role of ligands and receptors, and the use of multivalency in targeting. Various ligand-receptor pairs and receptor types are explored, along with the concepts of binding strength and multivalency theory. Examples of antigen-B cell binding and the use of multivalency in targeting are presented.