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This lecture introduces the basics of immune engineering, focusing on the use of materials in the field. It covers topics such as biomaterials, polymers, nanoparticles, surfaces, materials for drug delivery, cell adhesion, immune engineering, tissue engineering, measurements, regulations, and translation. The lecture also discusses the immune system, vaccination, anti-cancer immunotherapy, and examples of current research, including biopolymer-based expansion of tumor-specific T cells and implantable alginate scaffolds. Different types of vaccines, their components, and how vaccination prevents diseases are explained. The lecture concludes with insights into the development of vaccines, including the COVID-19 vaccine, and the challenges faced in cancer immunotherapy.