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This lecture delves into the statistical interpretation of entropy, focusing on micro and macro states of a system. Through examples like the Joule expansion, the instructor explains how different microstates can lead to the same macrostate, illustrating the concept with a system of colored balls. By analyzing the probabilities of various microstates in different scenarios, the lecture demonstrates how the most disordered state becomes the most probable as the number of particles increases, leading to a distribution centered around 50% for large particle numbers.