The Clinical Aspects of Covid-19

This lecture covers the immunology of SARS-CoV-2, acute phase symptoms related to the immune response, expression of ACE2 in various human organs, severe forms of Covid-19, and factors influencing disease severity. It discusses the role of innate and adaptive immune responses, the impact of ACE2 expression levels, thromboembolic events, imaging findings, and susceptibility factors such as age, gender, obesity, and comorbidities. The instructor explains the differences in immune responses between men and women, the implications of ACE2 downregulation in hypertension, and the systemic inflammatory nature of Covid-19, emphasizing genetic immune deficiencies, ACE2 expression reduction, and endothelial damage in severe cases.