Lecture
This lecture provides an overview of vaccine development, focusing on precision tumor recognition by T cells with combinatorial antigen-sensing circuits. It covers topics such as challenges in adoptive T cell therapy, engineering smarter T cells for immunotherapy, and the use of synthetic DNA nanocarriers to target T cells. The presentation delves into the impact of vaccination on human health, the history of immunology and vaccines, and the types of SARS-CoV-2 vaccines for COVID-19. The instructor discusses key cellular actors of adaptive immunity, the basic physiology of the primary immune response, and the activation of naive T cells by antigen-presenting cells.