Immune Tissue Engineering: Mechanisms and Applications

This lecture explores the field of immune tissue engineering, focusing on the central paradigms of cell expansion, manipulation, and signaling. It delves into the processes of haematopoiesis, immune cell types, and levels of the adaptive immune response. The lecture discusses the importance of engineering immune cells and tissues for targeted immunotherapeutics, such as CAR T cells and monoclonal antibodies, in treating various diseases. It also covers the engineering of primary immune tissues like bone marrow and thymus, highlighting their significance in understanding immunological mechanisms and developing therapies. The lecture emphasizes the role of engineered materials in regulating the immune response at the cellular, tissue, and organ levels.