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This lecture covers the primary and secondary lymphoid organs involved in the immune system, such as the thymus, bone marrow, lymph nodes, and spleen. It explains the development and maturation of T cells in the thymus, the circulation within the thymus, and the role of dendritic cells in antigen sampling. Additionally, it discusses the cell traffic within lymph nodes, the function of enterocytes and stem cells in intestinal tissue, and the importance of secondary lymphoid organs in initiating immune responses.