Enantioselective C-H Activation

This lecture covers enantioselective C-H activation reactions using various catalytic systems, such as Cu, Rh, and Ni catalysts, for functionalization of olefins, alkynes, and alkenes. The mechanisms of radical cyclization, metathesis, and reductive coupling are discussed, along with the use of ligands like JosiPhos and SEGPHOS. The lecture also explores the dual activation on a single metal center, non-activated system, and the combination of radical and metal pathways. Various asymmetric reactions, such as hydrogenation, hydroamination, and hydrocarbamoylation, are presented, highlighting the importance of ligand design and catalyst optimization.