This lecture discusses the influence of atoms in solid solution on the movement of dislocations, the nature of interactions between solute and dislocation, and the plasticity physics of single crystals. It covers topics such as the accommodation of dislocations, geometrically necessary dislocations, and the deformation of polycrystalline and multiphase metals. The lecture also explores the role of shear deformation, stress types, and the behavior of dislocations at different speeds. Emphasis is placed on the impact of thermal energy on processes like melting and diffusion mechanisms.