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This lecture explores the tissue engineering paradigm, focusing on the steps of cell isolation, seeding cells on a scaffold, cell stimulation in a bioreactor, and implantation of tissue engineered constructs. It delves into the potential of tailored-made polymers in the biomedical field, emphasizing the design, selection, and custom synthesis of polymers for various applications. The lecture also discusses the use of poly(urethane)s as biomaterials, their versatile nature, and the synthesis of biomedical polyesterurethanes. Furthermore, it presents success stories in tissue engineering, such as cardiac tissue engineering and peripheral nerve regeneration, showcasing the development of bioartificial materials and biomimetic scaffolds for stem cell-based therapies.